OcrV1, Main, Exploration, bibRecord, 000541

Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory inefficiency, and impaired autonomic control in heart failure

Identifieur interne : 000541 ( Main/Exploration ); précédent : 000540; suivant : 000542

Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory inefficiency, and impaired autonomic control in heart failure

Auteurs : Christos Manetos [Grèce] ; Stavros Dimopoulos [Grèce] ; Georgios Tzanis [Grèce] ; Stella Vakrou [Grèce] ; Athanasios Tasoulis [Grèce] ; Chris Kapelios [Grèce] ; Varvara Agapitou [Grèce] ; Argirios Ntalianis [Grèce] ; John Terrovitis [Grèce] ; Serafim Nanas [Grèce]

Source :

The Journal of heart and lung transplantation [ 1053-2498 ] ; 2011.

RBID : Pascal:12-0025954

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux autonome, Insuffisance cardiaque, Muscle strié, Exercice physique, Epreuve effort, Intolérance, Inefficacité, Commande, Contrôle, Appareil circulatoire, Cardiologie, Phlébologie.

English descriptors

KwdEn :
- Cardiology, Check, Circulatory system, Control, Diseases of the autonomic nervous system, Exercise tolerance test, Heart failure, Inefficiency, Intolerance, Phlebology, Physical exercise, Striated muscle.

Abstract

BACKGROUND: Several skeletal muscle abnormalities have been identified in patients with chronic heart failure (CHF), including endothelial dysfunction. We hypothesized that skeletal muscle microcirculation, assessed by near-infrared spectroscopy (NIRS), is impaired in CHF patients and is associated with disease severity. METHODS: Eighty-three stable patients with mild-moderate CHF (72 males, mean age 54 ± 14 years, body mass index 26.7 ± 3.4 kg/m²) and 8 healthy subjects, matched for age, gender and body mass index, underwent NIRS with the vascular occlusion technique and cardiopulmonary exercise testing (CPET) evaluation on the same day. Tissue oxygen saturation (StO₂, %), defined as the percentage of hemoglobin saturation in the microvasculature compartments, was measured in the thenar muscle by NIRS before, during and after 3-minute occlusion of the brachial artery. Measurements included StO₂, oxygen consumption rate (OCR, %/min) and reperfusion rate (RR, %/min). All subjects underwent a symptom-limited CPET on a cycle ergometer. Measurements included VO₂ at peak exercise (VO₂peak, ml/kg/min) and anaerobic threshold (VO₂AT, ml/kg/min), VE/VCO₂ slope, chronotropic reserve (CR, %) and heart rate recovery (HRR₁, bpm). RESULTS: CHF patients had significantly lower StO₂ (75 ± 8.2 vs 80.3 ± 6, p < 0.05), lower OCR (32.3 ± 10.4 vs 37.7 ± 5.5, p < 0.05) and lower RR (10 ± 2.8 vs 15.7 ± 6.3, p < 0.05) compared with healthy controls. CHF patients with RR ≥9.5 had a significantly greater VO₂peak (p < 0.001), VO₂AT (p < 0.01), CR (p = 0.01) and HRR, (p = 0.01), and lower VE/VCO₂ slope (p = 0.001), compared to those with RR <9.5. In a multivariate analysis, RR was identified as an independent predictor of VO₂peak, VE/VCO₂ slope and HRR,. CONCLUSIONS: Peripheral muscle microcirculation, as assessed by NIRS, is significantly impaired in CHF patients and is associated with disease severity.

Affiliations:

Grèce

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Le document en format XML

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<series><title level="j" type="main">The Journal of heart and lung transplantation</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiology</term>
<term>Check</term>
<term>Circulatory system</term>
<term>Control</term>
<term>Diseases of the autonomic nervous system</term>
<term>Exercise tolerance test</term>
<term>Heart failure</term>
<term>Inefficiency</term>
<term>Intolerance</term>
<term>Phlebology</term>
<term>Physical exercise</term>
<term>Striated muscle</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux autonome</term>
<term>Insuffisance cardiaque</term>
<term>Muscle strié</term>
<term>Exercice physique</term>
<term>Epreuve effort</term>
<term>Intolérance</term>
<term>Inefficacité</term>
<term>Commande</term>
<term>Contrôle</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Phlébologie</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND: Several skeletal muscle abnormalities have been identified in patients with chronic heart failure (CHF), including endothelial dysfunction. We hypothesized that skeletal muscle microcirculation, assessed by near-infrared spectroscopy (NIRS), is impaired in CHF patients and is associated with disease severity. METHODS: Eighty-three stable patients with mild-moderate CHF (72 males, mean age 54 ± 14 years, body mass index 26.7 ± 3.4 kg/m<sup>2</sup>
) and 8 healthy subjects, matched for age, gender and body mass index, underwent NIRS with the vascular occlusion technique and cardiopulmonary exercise testing (CPET) evaluation on the same day. Tissue oxygen saturation (StO<sub>2</sub>
, %), defined as the percentage of hemoglobin saturation in the microvasculature compartments, was measured in the thenar muscle by NIRS before, during and after 3-minute occlusion of the brachial artery. Measurements included StO<sub>2</sub>
, oxygen consumption rate (OCR, %/min) and reperfusion rate (RR, %/min). All subjects underwent a symptom-limited CPET on a cycle ergometer. Measurements included VO<sub>2</sub>
 at peak exercise (VO<sub>2</sub>
peak, ml/kg/min) and anaerobic threshold (VO<sub>2</sub>
AT, ml/kg/min), VE/VCO<sub>2</sub>
 slope, chronotropic reserve (CR, %) and heart rate recovery (HRR<sub>1</sub>
, bpm). RESULTS: CHF patients had significantly lower StO<sub>2</sub>
 (75 ± 8.2 vs 80.3 ± 6, p < 0.05), lower OCR (32.3 ± 10.4 vs 37.7 ± 5.5, p < 0.05) and lower RR (10 ± 2.8 vs 15.7 ± 6.3, p < 0.05) compared with healthy controls. CHF patients with RR ≥9.5 had a significantly greater VO<sub>2</sub>
peak (p < 0.001), VO<sub>2</sub>
AT (p < 0.01), CR (p = 0.01) and HRR, (p = 0.01), and lower VE/VCO<sub>2</sub>
 slope (p = 0.001), compared to those with RR <9.5. In a multivariate analysis, RR was identified as an independent predictor of VO<sub>2</sub>
peak, VE/VCO<sub>2</sub>
 slope and HRR,. CONCLUSIONS: Peripheral muscle microcirculation, as assessed by NIRS, is significantly impaired in CHF patients and is associated with disease severity.</div>
</front>
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<affiliations><list><country><li>Grèce</li>
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<tree><country name="Grèce"><noRegion><name sortKey="Manetos, Christos" sort="Manetos, Christos" uniqKey="Manetos C" first="Christos" last="Manetos">Christos Manetos</name>
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<name sortKey="Agapitou, Varvara" sort="Agapitou, Varvara" uniqKey="Agapitou V" first="Varvara" last="Agapitou">Varvara Agapitou</name>
<name sortKey="Dimopoulos, Stavros" sort="Dimopoulos, Stavros" uniqKey="Dimopoulos S" first="Stavros" last="Dimopoulos">Stavros Dimopoulos</name>
<name sortKey="Kapelios, Chris" sort="Kapelios, Chris" uniqKey="Kapelios C" first="Chris" last="Kapelios">Chris Kapelios</name>
<name sortKey="Nanas, Serafim" sort="Nanas, Serafim" uniqKey="Nanas S" first="Serafim" last="Nanas">Serafim Nanas</name>
<name sortKey="Ntalianis, Argirios" sort="Ntalianis, Argirios" uniqKey="Ntalianis A" first="Argirios" last="Ntalianis">Argirios Ntalianis</name>
<name sortKey="Tasoulis, Athanasios" sort="Tasoulis, Athanasios" uniqKey="Tasoulis A" first="Athanasios" last="Tasoulis">Athanasios Tasoulis</name>
<name sortKey="Terrovitis, John" sort="Terrovitis, John" uniqKey="Terrovitis J" first="John" last="Terrovitis">John Terrovitis</name>
<name sortKey="Tzanis, Georgios" sort="Tzanis, Georgios" uniqKey="Tzanis G" first="Georgios" last="Tzanis">Georgios Tzanis</name>
<name sortKey="Vakrou, Stella" sort="Vakrou, Stella" uniqKey="Vakrou S" first="Stella" last="Vakrou">Stella Vakrou</name>
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{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    OcrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0025954
   |texte=   Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory inefficiency, and impaired autonomic control in heart failure
}}

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Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory inefficiency, and impaired autonomic control in heart failure

Skeletal muscle microcirculatory abnormalities are associated with exercise intolerance, ventilatory inefficiency, and impaired autonomic control in heart failure

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